Gao et al. 2023: ChatGPT-generated scientific abstracts against the GPT-2 Output Detector and blinded reviewers

Authors
Gao, Howard, Markov, Dyer, Ramesh, Luo, Pearson
Venue
npj Digital Medicine 6, article 75
Published
AIDI-S-0013

Updated ·

The 2023 Gao study ran 50 ChatGPT-written medical abstracts and the 50 real abstracts they imitated through the GPT-2 Output Detector and reports an AUROC of 0.94, with blinded human reviewers catching 68% of the generated abstracts and wrongly flagging 14% of the real ones. The paper, "Comparing scientific abstracts generated by ChatGPT to real abstracts with detectors and blinded human reviewers" by Catherine A. Gao, Frederick M. Howard, Nikolay S. Markov, Emma C. Dyer, Siddhi Ramesh, Yuan Luo and Alexander T. Pearson, was published as a brief communication in npj Digital Medicine, volume 6, article 75, on 26 April 2023 (DOI 10.1038/s41746-023-00819-6, read 9 November 2026).

Gao et al. 2023: ChatGPT-generated scientific abstracts against the GPT-2 Output Detector and blinded reviewers: register plate with the page title and its register ID
The record plate: register ID and title, drawn from the index data.

This record joins the studies index as the only record built on scientific abstracts and the only one to put a detector beside human readers on the same texts. The paper was received on 1 January 2023 and accepted on 30 March 2023, and is open access (nature.com article page, read 9 November 2026).

Gao 2023 used one AI output detector, the GPT-2 Output Detector, a RoBERTa-based classifier that returns a "fake" score from 0.02% to 99.98%. Two similarity checkers, the free Plagiarism Detector website and the paid iThenticate, and four blinded human reviewers were run on the same abstracts for comparison; neither checker is an AI detector, so neither has a row below (DOI 10.1038/s41746-023-00819-6, Methods, read 9 November 2026).

What was tested

Detectors tested

The 1 detectors tested and their index cards
DetectorIndex card
GPT-2 Output DetectorGPT-2 Output Detector

Sample

The sample as the paper describes it
Text setCountSource
Original abstracts50Nature Medicine, JAMA, NEJM, BMJ, The Lancet, late November and December 2022 issues
Generated abstracts50ChatGPT, 15 December 2022 version, one prompt per title, first output
Abstracts scored by each blinded reviewer25Four reviewers, original or generated assigned by coin flip per pair

Detector as named in Gao et al. 2023, DOI 10.1038/s41746-023-00819-6.

The 50 original abstracts came from issues of Nature Medicine, JAMA, NEJM, BMJ and The Lancet published in late November and December 2022. For each, ChatGPT (the 15 December version) was given the prompt "Please write a scientific abstract for the article [title] in the style of [journal] at [link]" in a new session, and the first output was kept without editing (DOI 10.1038/s41746-023-00819-6, Methods, read 9 November 2026).

Sample as described in Gao et al. 2023, DOI 10.1038/s41746-023-00819-6.

The detector's scores were compared between the two sets and summarised as an ROC curve. The reviewers, four study team members used to reading abstracts, were told the set was a mixture, given 25 abstracts each and asked for a binary original-or-generated verdict with free-text notes; for each pair of reviewers an electronic coin flip decided which of them saw the original and which the generated version (DOI 10.1038/s41746-023-00819-6, Methods, read 9 November 2026).

What the study reports

Results as the study reports them, with their base
MetricValueBase
GPT-2 Output Detector, AUROC0.9450 original and 50 generated abstracts
GPT-2 Output Detector, median "fake" score on generated abstracts99.98% (IQR 12.73% to 99.98%)50 generated abstracts
GPT-2 Output Detector, median "fake" score on original abstracts0.02% (IQR 0.02% to 0.09%)50 original abstracts
GPT-2 Output Detector, sensitivity and specificity at the 1.46% cutoff86% and 94%50 generated, 50 original
Blinded reviewers, generated abstracts identified as generated68%generated abstracts reviewed
Blinded reviewers, original abstracts identified as original86%original abstracts reviewed
Blinded reviewers, original abstracts wrongly called generated14%original abstracts reviewed
Plagiarism Detector website, median "plagiarized" score, original and generated62.5% and 0%50 and 50 abstracts
iThenticate, median similarity index, original and generated100 and 2750 and 50 abstracts
Generated abstracts using the journal's own heading format8 (16%)50 generated abstracts

Gao 2023 reports medians with interquartile ranges for the scores and a single ROC curve for the detector; the reviewer figures are percentages of the abstracts in each class (DOI 10.1038/s41746-023-00819-6, Results and Figure 2, read 9 November 2026).

Values as printed in Gao et al. 2023, DOI 10.1038/s41746-023-00819-6.

The interquartile range is the detail to read: the lower quartile of the generated abstracts scored 12.73% "fake", so a quarter of ChatGPT's abstracts sat at or below that score while the real abstracts clustered at 0.02%, and Gao 2023 reports an optimal cutoff of 1.46% that gave sensitivity of 86% and specificity of 94% (DOI 10.1038/s41746-023-00819-6, Results, read 9 November 2026).

The reviewers and the detector disagreed about which abstracts were hard. Gao 2023 reports that the detector's scores did not differ (p = 0.45) between generated abstracts the reviewers caught and those they missed, and that reviewers described suspected abstracts as vague and formulaic, sometimes doubting real ones for including clinical trial registration numbers or alternative spellings (DOI 10.1038/s41746-023-00819-6, Results and Figure 4, read 9 November 2026).

The similarity checkers point the other way: generated abstracts scored a median 0% on the Plagiarism Detector website and 27 on iThenticate against 62.5% and 100 for the originals, because the text was new even though the numbers in it were invented; the patient cohort sizes ChatGPT invented correlated with the real ones at r = 0.76 (DOI 10.1038/s41746-023-00819-6, Results and Figure 1, read 9 November 2026). The authors conclude that AI output detectors "may serve as an editorial tool to help maintain scientific standards" depending on a publisher's guidelines.

Limits the authors state

The authors name the small sample size and the few reviewers first. They used a single fixed prompt without exploring variations, took only ChatGPT's first output for each title, and note that the model gives a different response each time, so the study "likely underestimates the ability of ChatGPT to generate scientific abstracts" (DOI 10.1038/s41746-023-00819-6, Discussion, read 9 November 2026).

The GPT-2 Output Detector accepts at most 510 tokens, so some abstracts could not be fully evaluated. The reviewers knew that part of their set was generated, which an editor reading a submission would not, and gave a binary verdict with no formal rubric (DOI 10.1038/s41746-023-00819-6, Discussion, read 9 November 2026). The paper tested no other AI detector and no field outside biomedical science, both of which the authors leave to future work.

An AUROC of 0.94 in Gao 2023 describes how well one 2019 detector separated 50 December 2022 ChatGPT abstracts from 50 journal abstracts (DOI 10.1038/s41746-023-00819-6); it is not an accuracy rate for any product on any other text.

Which cards this study feeds

The one detector in Gao 2023 has a card in this index. The card records the AUROC of 0.94 on 100 abstracts, the 86% sensitivity and 94% specificity at the 1.46% cutoff, and the medians of 99.98% and 0.02% (DOI 10.1038/s41746-023-00819-6, read 9 November 2026).

The card appears in the ranking of detectors by independent test record, and the 94% specificity on 50 real abstracts is the kind of figure the false positive rate ranking draws on. How this record is sourced explains how a specificity on a stated base enters a card, and the home page lists which AI detectors exist and who has tested them.

Related records: Weber-Wulff 2023 tested the same GPT-2 Output Detector on 54 documents that spring and scored it 39 of 54, and Orenstrakh 2023 found it tied second of eight tools on 134 English coursework texts with 2 false positives in 114 (DOI 10.1038/s41746-023-00819-6, read 9 November 2026).

The researchers view reads this record as the index's only result on scientific writing, beside the nineteen cards whose stated limits or upload formats take a full manuscript.

Questions about this study

How accurate was the GPT-2 Output Detector in Gao 2023?

An AUROC of 0.94 on 50 ChatGPT abstracts and 50 real ones, with sensitivity of 86% and specificity of 94% at the cutoff of 1.46% that the authors chose (DOI 10.1038/s41746-023-00819-6). Gao 2023 gives the median "fake" score as 99.98% for generated and 0.02% for original abstracts.

How well did human reviewers do in Gao 2023?

They identified 68% of generated abstracts as generated and 86% of real abstracts as real, which means 32% of ChatGPT's abstracts passed and 14% of real abstracts were wrongly called generated (DOI 10.1038/s41746-023-00819-6). Gao 2023 used four blinded reviewers with 25 abstracts each.

Did plagiarism checkers catch the ChatGPT abstracts in Gao 2023?

No: the generated abstracts scored a median 0% on the Plagiarism Detector website and a median similarity index of 27 on iThenticate, against 62.5% and 100 for the original abstracts, because the generated text matched nothing published (DOI 10.1038/s41746-023-00819-6). Gao 2023 treats this as a reason similarity checking cannot stand in for AI detection.

How many abstracts did Gao 2023 test?

One hundred: 50 original abstracts from Nature Medicine, JAMA, NEJM, BMJ and The Lancet, and 50 generated by ChatGPT from their titles using one fixed prompt, taking the first output each time (DOI 10.1038/s41746-023-00819-6). The authors of Gao 2023 name the sample size as the study's first limitation.

Source and revisions

Source

Gao, C. A., Howard, F. M., Markov, N. S., Dyer, E. C., Ramesh, S., Luo, Y., Pearson, A. T. (2023). Comparing scientific abstracts generated by ChatGPT to real abstracts with detectors and blinded human reviewers. npj Digital Medicine 6, 75. https://doi.org/10.1038/s41746-023-00819-6, read 9 November 2026 at https://www.nature.com/articles/s41746-023-00819-6.

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